AB258. Effect and mechanism of grape seed proanthocyanidin extract (GSPE) on diabetes-induced bladder dysfunction

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Effects of Grape Seed Proanthocyanidin Extract on Oxidative Stress Induced by Diabetes in Rat Kidney

Background: This study examined the effect of grape seed proanthocyanidin extract (GSPE) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. Methods: Thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg GSPE for 6 w...

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Grape Seed Proanthocyanidin Extract Ameliorates Diabetic Bladder Dysfunction via the Activation of the Nrf2 Pathway

Diabetes Mellitus (DM)-induced bladder dysfunction is predominantly due to the long-term oxidative stress caused by hyperglycemia. Grape seed proanthocyanidin extract (GSPE) has been reported to possess a broad spectrum of pharmacological and therapeutic properties against oxidative stress. However, its protective effects against diabetic bladder dysfunction have not been clarified. This study ...

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Effects of grape seed proanthocyanidin extract on oxidative stress induced by diabetes in rat kidney.

BACKGROUND This study examined the effect of grape seed proanthocyanidin extract (GSPE) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. METHODS Thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg GSPE for 6 w...

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Grape seed proanthocyanidin extract protects lymphocytes against histone-induced apoptosis

Apoptosis of lymphocytes is associated with immunosuppression and poor prognosis in sepsis. Our previous report showed that histones, nuclear proteins released from damaged or dying cells in sepsis, can mediate lymphocyte apoptosis via mitochondria damage. Grape seed proanthocyanidin extract (GSPE), a natural substance with protective properties against oxidative stress, plays a vital role in c...

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effects of grape seed proanthocyanidin extract on oxidative stress induced by diabetes in rat kidney

background: this study examined the effect of grape seed proanthocyanidin extract (gspe) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. methods: thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg gspe for 6 w...

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ژورنال

عنوان ژورنال: Translational Andrology and Urology

سال: 2016

ISSN: 2223-4683,2223-4691

DOI: 10.21037/tau.2016.s258